warum nehme ich trotz sport und kaloriendefizit nicht ab — can a DNA test help?

The question of why you are not losing weight despite exercise and a calorie deficit is multifactorial: hormonal imbalances (cortisol, thyroid), poor sleep, stress, muscle gain masking fat loss, inaccurate calorie tracking, or metabolic adaptation. Can a DNA test help? Only to a very limited extent. MyBody-X DNA tests do not include the well-studied obesity genes FTO and MC4R; they cover APOE, APOA5, MTHFR, and HLA-DQA1, which have small effects on lipid and folate metabolism. The 'WeightLoss DNA' test is marketed as lifestyle inspiration, not a clinically validated weight-loss tool. Effect sizes from GWAS are small, and no robust evidence supports using these SNPs to overcome a weight-loss plateau. A DNA test might hint at macronutrient tendencies, but it cannot replace a thorough medical workup (thyroid, insulin, cortisol, microbiome). In summary, while a DNA test can be a curiosity-driven add-on, it is not a reliable diagnostic tool for explaining a stalled weight loss. Lifestyle and medical factors dominate.