Whether lowering cortisol is useful for longevity is not conclusively proven by current evidence. Cortisol, the primary stress hormone, becomes chronically elevated under persistent stress. High cortisol levels are linked to accelerated cellular aging, increased inflammation, insulin resistance, and cardiovascular risk—all factors that may shorten lifespan. Therefore, reducing cortisol through stress management, adequate sleep, exercise, and a balanced diet is a plausible strategy to support healthy aging. However, no randomized controlled trials directly demonstrate that lowering cortisol extends human lifespan. The evidence is largely mechanistic and observational. Moreover, cortisol is essential for normal physiology; excessive or pharmacological reduction can be harmful. For consumers of MyBody-X tests, single biomarkers or genetic variants (e.g., in the glucocorticoid receptor gene) have limited predictive power. A holistic lifestyle approach is more effective than focusing on one parameter.
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