What to watch with ADH1B and fertility?

ADH1B encodes an alcohol dehydrogenase enzyme. Variants like ADH1B*2 (rs1229984) cause faster ethanol metabolism and often aversive reactions, leading to lower alcohol intake. Since alcohol is a known teratogen in pregnancy and can impair sperm quality, genetically reduced consumption may indirectly benefit fertility. However, direct human studies linking ADH1B to fertility outcomes are limited and mostly mechanistic. Evidence grade: mechanistic. A genetic test alone does not provide clinical guidance. For those planning pregnancy, the focus should remain on evidence-based lifestyle measures: avoiding alcohol, optimizing nutrition, and managing stress. Always consult a healthcare provider for personalized advice.