CRP (C-reactive protein) is a classic inflammation marker produced in the liver. Chronic stress can promote low-grade systemic inflammation via activation of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system, potentially raising CRP levels. However, the provided context does not contain direct evidence for this link. The evidence is primarily mechanistic and epidemiological, not from human RCTs in this specific context. Elevated CRP is a non-specific risk marker – it indicates inflammation but not its cause. Therefore, a CRP test alone cannot diagnose stress. For a holistic assessment, other stress markers (cortisol, alpha-amylase) and lifestyle factors should be considered. Caveat: The utility of CRP in the context of stress is limited; medical interpretation is required.
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