Risks and limits of Reis glutenfrei Test

The 'Reis glutenfrei Test' is not a standardized medical test. If it is a direct-to-consumer DNA test claiming to assess gluten intolerance or celiac risk, the risks and limits are substantial: such tests typically analyze only a few HLA variants (e.g., DQ2/DQ8) relevant for celiac disease, but not for non-celiac gluten sensitivity. A negative result does not rule out celiac disease, and a positive result does not mean disease—many carriers never develop symptoms. Moreover, clinical validation for the specific test platform is often lacking. Evidence is weak (marketing/unclear). Before adopting a gluten-free diet, clinical evaluation with serology and biopsy is essential. Self-initiated dietary changes can cause nutrient deficiencies and obscure diagnostic markers.