warum nehme ich trotz kaloriendefizit nicht ab — can a DNA test help?

The question of why weight loss stalls despite a calorie deficit is multifactorial: metabolic adaptation, hormonal changes (leptin, cortisol), sleep, stress, medications, gut microbiome, and often inaccurate tracking of actual intake or expenditure. A DNA test offers limited help. While certain variants (e.g., FTO, MC4R) are associated with a slightly lower basal metabolic rate or altered fat oxidation, effect sizes are small and clinical relevance is unclear. Evidence comes mainly from GWAS and mechanistic studies, not from RCTs showing benefit for weight loss. Lifestyle factors and adherence to the deficit dominate. A DNA test may serve as an additional piece of the puzzle but cannot replace professional dietary counseling or medical workup (e.g., thyroid function, insulin resistance). Its predictive power is low, and results should not be used as sole guidance. Safety note: persistent weight plateau despite a true deficit warrants medical evaluation to rule out underlying conditions.