What role does VDR play in longevity?

The provided context does not contain specific information about VDR and longevity. In general, VDR (vitamin D receptor) is involved in calcium homeostasis, immune modulation, and cell differentiation. Some population studies have linked VDR polymorphisms (e.g., FokI, BsmI) to age-related diseases, but the evidence is mixed and effect sizes are small. Longevity is a complex trait influenced by many genes, lifestyle, and environment. Without direct context, the role of VDR in longevity remains an area of ongoing research with no definitive conclusions. A consumer genetic test for VDR variants is not a validated tool for predicting lifespan. Evidence grade: unclear (no direct sources in context).