Evidence check: Progesteron in the context of allergy

The relationship between progesterone and allergies is not fully established. Progesterone can modulate the immune system, potentially shifting it toward a Th2-dominant response, which may promote allergic inflammation. Some women experience cyclical allergy or asthma symptoms (e.g., premenstrual asthma) correlating with high progesterone levels in the luteal phase. However, evidence is mixed: some studies suggest a protective effect, others an exacerbation. Progesterone is not a standard treatment for allergies; supplementation or hormone therapy should only be considered under medical supervision. Home tests for progesterone (e.g., saliva) provide a snapshot but are not validated for allergy diagnosis. The evidence level is 'human-moderate' to 'mixed' – observational and mechanistic studies exist, but no robust RCTs support clinical recommendations. Caveat: hormonal influences on allergies are highly individual. Always consult a physician for proper allergy testing and hormone assessment before making any therapeutic changes.