Can Progesteron help with longevity?

Whether progesterone can help with longevity is not clearly supported by current evidence. Progesterone is a key steroid hormone primarily involved in the menstrual cycle and pregnancy. Preclinical studies suggest it may have neuroprotective, anti-inflammatory, and bone-protective effects, and some research indicates it could influence cardiovascular health. However, robust human trials demonstrating a direct extension of lifespan are lacking. Hormone replacement therapy (often combined with estrogen) shows mixed results regarding overall mortality and disease risk. Moreover, effects depend heavily on dosage, timing, route of administration, and individual health status. Using progesterone solely for anti-aging purposes without medical indication is not recommended and may carry risks such as thromboembolism or hormonal imbalances. The evidence is moderate to mechanistic, not strong enough to support a longevity claim.