What role does Cortisol senken play in Langlebigkeit?

The role of lowering cortisol in longevity is not yet fully established by strong evidence. Cortisol, the primary human stress hormone, is regulated by the hypothalamic-pituitary-adrenal (HPA) axis. Chronically elevated cortisol levels are associated with several negative health outcomes: accelerated telomere shortening, increased insulin resistance, greater visceral fat accumulation, immunosuppression, and reduced neurogenesis. Epidemiological studies link high chronic stress to shortened lifespan. However, cortisol is essential for energy metabolism and immune function; excessive lowering (e.g., via drugs or adrenal insufficiency) is dangerous. Evidence for a direct longevity benefit from cortisol reduction through lifestyle interventions (meditation, sleep, diet) is mostly mechanistic, based on animal models or observational studies. Randomized controlled trials with longevity as an endpoint are lacking. Therefore, the evidence is mixed and inconclusive. MyBody-X tests do not measure cortisol levels or provide direct recommendations for lowering it. Any interpretation should be part of a comprehensive stress management approach.