Is Folsäure useful for Müdigkeit?

Whether folic acid helps with fatigue depends on the underlying cause. Folic acid (vitamin B9) is crucial for red blood cell formation and homocysteine metabolism. A deficiency can cause megaloblastic anemia, whose hallmark symptom is fatigue. In such cases, supplementation can effectively resolve fatigue. However, folate deficiency is uncommon in the general population with adequate diets. For fatigue without proven deficiency, there is no strong evidence that folic acid provides benefit. Moreover, high folic acid intake can mask vitamin B12 deficiency, which itself causes fatigue. The evidence is mixed: observational studies link low folate levels to fatigue, but randomized controlled trials in non-deficient individuals are lacking. Direct-to-consumer genetic tests claiming 'folic acid sensitivity' are not evidence-based. Conclusion: Without a medically confirmed deficiency or risk factors (e.g., pregnancy, malabsorption), folic acid supplementation for fatigue is not recommended. Persistent fatigue warrants a thorough medical workup.