How are tTG IgA and Langlebigkeit related?

tTG IgA (tissue transglutaminase IgA) is a specific biomarker for celiac disease, an autoimmune condition triggered by gluten. Elevated tTG IgA indicates active celiac disease, which, if untreated, leads to chronic inflammation, malabsorption, and nutrient deficiencies—factors that increase the risk of osteoporosis, certain cancers (e.g., intestinal lymphoma), and premature mortality. Strict adherence to a gluten-free diet normalizes tTG IgA levels within months and reduces mortality risk back to population levels. There is no direct evidence that tTG IgA itself is a longevity marker; the link is indirect via disease activity and complications. In healthy individuals without celiac disease, tTG IgA levels do not predict lifespan. Evidence comes from observational studies and clinical practice, not randomized longevity trials. Caveat: tTG IgA can be falsely negative in IgA deficiency; IgG-based tests or duodenal biopsy may be needed.