The combination of GLP-1 receptor agonists („weight loss injections“) with targeted nutrition is useful when medication-induced weight loss is supported by a sustainable dietary strategy. Clinical trials demonstrate that semaglutide and liraglutide effectively reduce appetite and caloric intake, but without proper nutritional guidance, patients risk muscle loss, micronutrient deficiencies, and rebound weight gain. A diet rich in protein, fiber, and essential vitamins can mitigate these risks and enhance fat loss. Additionally, nutritional counseling is critical for maintaining weight after drug discontinuation. However, evidence for specific dietary protocols (e.g., low-carb vs. Mediterranean) remains limited; current guidelines recommend a personalized, calorie-controlled balanced diet. Importantly, the injection is not a substitute for healthy eating but a tool within a comprehensive program including exercise and behavioral change. Caveat: Long-term outcomes and optimal nutritional strategies are still under investigation. Evidence: human-strong for drug efficacy, moderate for specific dietary recommendations.
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