Evidence check: Insulin in the context of Müdigkeit

The link between insulin and fatigue is indirect, primarily mediated by metabolic dysfunction. Insulin resistance – often linked to obesity, inactivity, and genetic variants (e.g., TCF7L2 rs7903146) – impairs cellular glucose uptake, reducing energy availability and potentially contributing to chronic tiredness. Additionally, insulin resistance promotes low-grade inflammation (e.g., elevated IL‑6 via rs1800795), which can further exacerbate fatigue. The provided context does not include a direct study on insulin and fatigue; evidence is based on mechanistic pathways and population associations. Individual genetic variants have small effect sizes and are not diagnostic. Safety note: Persistent fatigue should prompt medical evaluation for insulin resistance or prediabetes, especially in the presence of risk factors like obesity or family history.