Can HDL help with menopause?

The question of whether HDL ('good' cholesterol) can help with menopause is complex. HDL is known for its role in reverse cholesterol transport and has anti-inflammatory and antioxidant properties. During menopause, estrogen levels decline, often leading to an increase in LDL cholesterol and a decrease in HDL cholesterol. Higher HDL is generally associated with a lower risk of cardiovascular disease. However, there is no strong evidence that specifically raising HDL levels (e.g., through drugs or supplements) directly alleviates menopausal symptoms like hot flashes or mood swings. Research suggests that HDL function (how well it works) may be more important than the mere quantity. Lifestyle measures such as regular exercise, a Mediterranean diet, and smoking cessation can positively influence HDL and simultaneously promote overall well-being during menopause. Nevertheless, the evidence for a specific HDL increase to relieve symptoms is weak and based mainly on mechanistic considerations and observational studies. Clinical trials with HDL-raising drugs have often shown no benefit for cardiovascular endpoints, highlighting the complexity. Therefore, the focus should be on a healthy lifestyle rather than the targeted manipulation of a single biomarker.