How are IgG and menopause related?

The relationship between IgG antibodies and menopause is not well established in the scientific literature. During menopause, declining estrogen levels can modulate immune function, potentially affecting IgG production. Some observational studies report minor shifts in IgG subclasses, but effect sizes are small and highly variable between individuals. MyBody-X offers IgG4 food sensitivity tests, but these are not validated for assessing menopause-related immune changes. The evidence is primarily mechanistic and observational, lacking robust clinical trials. Therefore, no reliable conclusions about menopause can be drawn from IgG testing. Women experiencing menopausal symptoms should consult a gynecologist or endocrinologist rather than rely on direct-to-consumer antibody tests.