What role does Testosteron play in Langlebigkeit?

Testosterone plays a complex and partly contradictory role in longevity. As men age, testosterone levels naturally decline, and low levels are associated with sarcopenia, reduced bone density, increased fracture risk, and lower quality of life – factors that can negatively impact lifespan. Conversely, some epidemiological studies suggest that very high testosterone levels in men may be linked to increased risks of cardiovascular events and prostate cancer, potentially shortening lifespan. However, the evidence is not clear-cut: recent meta-analyses show no consistent association between testosterone and all-cause mortality. Effects also vary by sex, age, and health status. Testosterone therapy in older men with confirmed deficiency can improve physical function but carries risks. For women, data are even scarcer. In summary, an optimal, age-appropriate testosterone level appears beneficial for health in aging, but a causal role in longevity is not established. Evidence is moderate, based on observational studies; long-term randomized trials are lacking.