Myths vs facts: BDNF and Sport

BDNF (Brain-Derived Neurotrophic Factor) is a protein that supports neuroplasticity and is robustly increased by exercise. A common myth is that only high-intensity endurance training boosts BDNF – in reality, moderate activities like brisk walking or cycling also significantly elevate BDNF levels. Another myth is that BDNF supplements can replace exercise; evidence for oral supplementation is weak, while exercise-induced release is well-documented. Fact: Regular physical activity increases BDNF, which is linked to improved cognition, mood, and memory. Genetic tests for BDNF variants (e.g., rs6265 Val66Met) exist, but effect sizes are small and not actionable for personalized training. The evidence for BDNF and sport is human-strong, but the clinical utility of single-gene testing remains limited. Caution: BDNF is just one piece of the complex exercise adaptation puzzle; overall training, nutrition, and recovery matter more.