Evidence check: DNA Stoffwechseltest in the context of Wechseljahre

Evidence for DNA metabolism tests in menopause is weak to moderate. While some gene variants (e.g., FTO, GHRL) show small associations with weight and appetite, effects are modest and strongly modified by lifestyle, hormonal changes, and diet. Menopause itself alters metabolism due to estrogen decline, so a genetic test adds limited predictive value. Direct-to-consumer tests often overstate clinical relevance. MyBody-X is not a medical diagnostic. Focus on evidence-based lifestyle: protein-rich diet, resistance training, sleep hygiene, and stress management. Blood markers like fasting insulin, HbA1c, or hsCRP may be more actionable. Evidence: human-observational/GWAS, not menopause-specific. Beware of exaggerated claims.