How are Folsäure and longevity related?

The relationship between folic acid (vitamin B9) and longevity is complex and not fully resolved. Folic acid is crucial for DNA synthesis, cell division, and homocysteine metabolism. Elevated homocysteine is a risk factor for cardiovascular disease and cognitive decline, which can shorten lifespan. Studies suggest that adequate folate intake—especially from food sources like leafy greens—is associated with lower homocysteine and reduced risk of age-related diseases. However, evidence for a direct extension of lifespan through folic acid supplementation in well-nourished populations is weak. Large randomized trials have not shown clear benefits for all-cause mortality. Safety concerns exist: high doses can mask vitamin B12 deficiency and may increase cancer risk. Genetic variants like MTHFR (e.g., rs1801133) affect folate metabolism, but their relevance to longevity is unclear. Consumer DNA tests often oversimplify these interactions. In summary, a balanced diet rich in natural folate is beneficial, but high-dose supplementation solely for longevity is not evidence-based.