Progesterone is often marketed for skin benefits, but the evidence is mixed. **Fact:** Progesterone can modulate sebum production and may help some women with hormonal acne, especially during the luteal phase. **Myth:** It is not a proven anti-aging agent – effects on collagen synthesis are weak and not supported by large trials. Topical progesterone is sold in anti-aging creams, but skin absorption is low and long-term safety is unclear. **Caveat:** In systemic hormone therapy, progesterone can influence skin barrier function but also carries risks like fluid retention or mood changes. Most evidence is mechanistic or from small observational studies. For skin concerns, consult a dermatologist rather than relying solely on consumer hormone tests.
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