Ferritin is a key iron-storage protein and a critical marker, especially in seniors. Low ferritin (<30 ng/mL) indicates iron deficiency, common in older adults due to chronic blood loss (e.g., gastrointestinal), poor absorption, or chronic disease. High ferritin (>300 ng/mL) may signal iron overload (hemochromatosis) but also reflects an acute-phase response to inflammation, infection, or malignancy. Because ferritin is an acute-phase reactant, it must be interpreted alongside CRP, transferrin, and serum iron. In seniors, caution is essential: iron deficiency should be corrected, but indiscriminate iron supplementation can be harmful in chronic inflammatory conditions or undiagnosed hemochromatosis. A single ferritin test is insufficient; a full iron panel and medical evaluation are required. Evidence for general ferritin interpretation is strong, but senior-specific nuances (comorbidities, polypharmacy) are moderately supported. Always consult a physician before supplementing.
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