How are IgE and Allergie related?

IgE (Immunoglobulin E) is the antibody class most closely linked to allergic reactions. When a person is sensitized to an allergen (e.g., pollen, pet dander, food), their immune system produces allergen-specific IgE. These IgE molecules bind to high-affinity receptors on mast cells and basophils. Upon re-exposure, the allergen cross-links the IgE, triggering degranulation and release of histamine, leukotrienes, and other mediators. This causes the classic symptoms of allergy: sneezing, itching, hives, wheezing, and in severe cases anaphylaxis. Total IgE levels or specific IgE tests (e.g., ImmunoCAP) are used in allergy diagnosis, but elevated IgE alone does not confirm allergy – it must be correlated with clinical history. Other conditions (parasitic infections, certain immune disorders) can also raise IgE. The evidence for the IgE–allergy link is strong (human-strong), based on decades of immunological and clinical research. However, the provided context does not contain specific studies or sources on this topic; the answer relies on established medical knowledge. Caveat: IgE testing is a tool, not a standalone diagnosis; always consult an allergist for interpretation.