What role does MTHFR play in Allergie?

The role of MTHFR in allergies is not scientifically well-established. MTHFR is a key enzyme in folate metabolism, influencing methylation and homocysteine levels. Impaired methylation could theoretically affect immune regulation and potentially contribute to allergic responses. However, robust clinical studies directly linking MTHFR variants (e.g., C677T) to allergies such as hay fever, asthma, or atopic dermatitis are lacking. Existing evidence comes mostly from small association studies with inconsistent results. Moreover, the health effects of MTHFR polymorphisms are generally modest and can be modified by adequate folate intake (e.g., from leafy greens). Direct-to-consumer DNA tests often overstate the clinical significance of such variants. If homocysteine is elevated, targeted supplementation (e.g., active folate) may be considered, but an MTHFR variant alone does not warrant allergy treatment. For suspected allergies, established diagnostic methods (skin tests, specific IgE) and medical evaluation are essential.