What role does Folsäure play in Fruchtbarkeit?

Folic acid (vitamin B9) is critical for cell division and DNA synthesis, making it relevant for fertility in both sexes. In women, adequate intake supports ovulation quality and reduces neural tube defect risk – hence the recommendation of 400 µg/day before and during pregnancy. In men, observational studies suggest a positive link between folate levels and sperm quality (motility, morphology), but randomized controlled trials are scarce and show mixed results. The evidence for a direct causal effect on fertility is therefore moderate. Higher doses (e.g., 5 mg/day) are only advised for specific indications (e.g., MTHFR mutation), as indiscriminate high dosing carries potential risks (e.g., masking B12 deficiency). A genetic test for MTHFR variants can provide insights but does not replace medical advice. Overall, folic acid is an important but not sole factor for fertility; balanced nutrition and lifestyle factors are equally crucial.