Myths vs facts: Folsäure and gut health

The claim that folic acid directly improves gut health is not well supported by evidence. Folic acid (vitamin B9) is crucial for cell division and DNA synthesis, and deficiency can impair the intestinal lining. However, no robust studies show that supplementation beyond meeting requirements positively alters the gut microbiome or reduces intestinal inflammation. Most consumer 'gut health' tests analyzing folic acid levels or genetic variants (e.g., MTHFR) overstate clinical relevance. An MTHFR polymorphism can impair conversion of folic acid to its active form (5-MTHF), but effects on gut health are individual and not predictable. Additionally, high folic acid intake can mask vitamin B12 deficiency. Bottom line: folic acid is essential, but 'gut health' claims are often marketing. A balanced diet rich in natural folate (leafy greens, legumes) is more advisable than high-dose supplements without medical indication.