Ferritin is a key marker of iron stores, but in seniors its interpretation is nuanced. Low ferritin (<30 ng/mL) typically indicates iron deficiency, common in the elderly due to gastrointestinal bleeding, poor diet, or malabsorption. High ferritin (>200–300 ng/mL in men, >150–200 ng/mL in women) is often misinterpreted: it can reflect iron overload (hemochromatosis) but more frequently rises as an acute-phase reactant due to inflammation, infection, liver disease, or malignancy. In seniors with chronic conditions (e.g., rheumatoid arthritis, CKD), elevated ferritin is often inflammatory rather than indicating excess iron. To differentiate, measure CRP, transferrin saturation, and complete blood count. Genetic testing for HFE mutations (C282Y, H63D) is warranted only if ferritin is persistently high without inflammation. MyBody-X offers ferritin testing, but results must be reviewed by a physician. Evidence is mixed: robust clinical guidelines exist, but individual variability is high. Safety note: In seniors with renal or hepatic impairment, ferritin may be misleading. Always consult a doctor before taking supplements or undergoing phlebotomy.
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