Myths vs facts: hsCRP and Fruchtbarkeit

The question of myths vs facts regarding hsCRP (high-sensitivity C-reactive protein) and fertility is important but often oversimplified. hsCRP is a nonspecific marker of systemic inflammation. Elevated levels have been associated with reduced fertility in women (e.g., impaired ovulation, implantation failure, endometriosis) and men (e.g., lower sperm quality). However, hsCRP is not a direct fertility test. Many lifestyle factors – diet, stress, sleep, infections, obesity – influence hsCRP. A single elevated reading does not predict infertility. Myth: A normal hsCRP guarantees fertility. Fact: hsCRP can be a useful adjunct in evaluating conditions like PCOS or metabolic syndrome, but it does not replace comprehensive fertility workup. Evidence comes from observational studies; RCTs targeting hsCRP reduction to improve fertility are lacking. Therefore, hsCRP is a risk marker, not a diagnostic tool. Caveat: No clinical guideline currently recommends routine hsCRP screening for fertility. For those trying to conceive, a medical evaluation is essential.