What role does FTO play in Langlebigkeit?

FTO (Fat Mass and Obesity Associated) is primarily known for its association with obesity risk. While obesity can indirectly affect lifespan through metabolic diseases, direct evidence linking FTO variants to longevity is weak. Most longevity research focuses on genes like FOXO3, APOE, and SIRT1. FTO variants (e.g., rs9939609) have small effects on BMI (1–3 kg), but their impact on lifespan is not established. Observational studies show that FTO-related obesity may reduce life expectancy, but this is mediated by lifestyle factors. Consumer tests like MyBody-X may report FTO, but the results are not diagnostic for longevity. Evidence grade: human-observational for obesity; for longevity, it is speculative. A healthy diet and exercise remain far more important.