How are Folsäure and stress related?

Folic acid (vitamin B9) is essential for methylation and the synthesis of neurotransmitters like serotonin and dopamine, which regulate mood. Chronic stress can increase folate demand because stress hormones such as cortisol affect methylation pathways. Some observational studies link low folate levels to a higher risk of depression and anxiety. However, evidence for a direct stress-reducing effect of folic acid supplementation in healthy individuals without deficiency is limited. Most data come from observational studies, not randomized controlled trials. Additionally, genetic variants (e.g., in the MTHFR gene) can influence folate metabolism, potentially modulating individual responses to stress. A balanced diet rich in folate (leafy greens, legumes) is advisable. Over-supplementation should be avoided due to possible adverse effects. Overall, the relationship between folic acid and stress is complex and not sufficiently supported to recommend routine supplementation for stress reduction.