Evidence check: HDL in the context of Fruchtbarkeit

The role of HDL (high-density lipoprotein) in fertility is not well-established scientifically. HDL is primarily known as 'good' cholesterol for cardiovascular health. Some observational studies suggest associations between low HDL levels and reduced fertility – for example, in women with PCOS or men with poor sperm quality. However, the evidence is mostly associative, not causal. Direct genetic tests linking HDL specifically to fertility are not validated. Consumer DNA tests like MyBody-X may report HDL-related SNPs (e.g., in CETP, LIPC), but their clinical utility for fertility is low. Lifestyle factors such as diet, exercise, and weight management have a stronger impact on both HDL and fertility. Medical evaluation for fertility issues should not rely on such tests. Evidence: mixed/unclear.