Myths vs facts: AMH and fatigue

AMH (anti-Müllerian hormone) is primarily a marker of ovarian reserve in women and is not validated for diagnosing or explaining fatigue. There is no direct scientific evidence linking AMH levels to general tiredness. Fatigue is multifactorial: poor sleep, stress, nutrient deficiencies (iron, vitamin D, B12), thyroid dysfunction, and mental health are common causes. While low AMH may indicate approaching menopause, which can be associated with fatigue due to estrogen decline and sleep disruption, the hormone itself is not a fatigue marker. Marketing that suggests AMH testing for fatigue is misleading. A single AMH test cannot explain chronic exhaustion. A thorough medical workup including CBC, thyroid panel, vitamins, and cortisol is more appropriate. Evidence grade: unclear – no established AMH-fatigue connection in current literature.