What role does Progesteron play in Langlebigkeit?

Progesterone is a steroid hormone primarily known for its role in the female reproductive cycle. Regarding longevity, evidence from animal and mechanistic studies suggests that progesterone may exert anti-inflammatory effects, reduce oxidative stress, and offer neuroprotection. These mechanisms could theoretically slow aspects of aging. However, direct human evidence for lifespan extension is very weak. Most data come from cell culture or rodent models, and human interventional studies are lacking. Furthermore, progesterone's effects are highly context-dependent (e.g., menstrual cycle, menopause, hormone replacement therapy). Uncritical use of progesterone for 'anti-aging' is not recommended due to potential risks such as thrombosis and hormone-sensitive cancers. In summary, progesterone may have favorable effects on some aging biomarkers, but a proven role in longevity is absent. The evidence is mechanistic and unclear.