What to watch with tTG IgA and fatigue?

tTG IgA is a serological marker used primarily for celiac disease screening. Fatigue is a common symptom of celiac disease, but it is highly nonspecific. Elevated tTG IgA alone does not confirm celiac disease; a duodenal biopsy is required for diagnosis. False positives can occur due to IgA deficiency, other autoimmune conditions, or laboratory error. If you have fatigue and positive tTG IgA, consult a gastroenterologist for proper evaluation. A gluten-free diet should not be started before diagnosis, as it can interfere with biopsy results. Other causes of fatigue (e.g., iron deficiency, thyroid dysfunction, sleep disorders) should also be considered. The evidence linking tTG IgA to fatigue is moderate, as many individuals with elevated antibodies are asymptomatic. Watch for additional symptoms like diarrhea, bloating, or weight loss. Genetic testing for HLA-DQ2/DQ8 can help rule out celiac disease but is not diagnostic.