What to watch with HLA-DQ2 and Sport?

HLA-DQ2 is a genetic risk factor for celiac disease, but not all carriers develop the condition. For athletes: if you have no symptoms like bloating, diarrhea, or fatigue after gluten-containing meals, there is no reason to worry. However, if you experience unexplained performance drops, digestive issues, or chronic fatigue, a gluten-free trial (e.g., 4 weeks) under medical supervision may be reasonable. A positive genetic test alone is not diagnostic – antibody tests and duodenal biopsy remain the gold standard. Evidence for performance benefits of a gluten-free diet in HLA-DQ2 carriers without celiac disease is weak. Be cautious of exaggerated claims from the sports community. If celiac disease is confirmed, strict gluten avoidance is essential to prevent nutrient malabsorption and inflammation.