What role does MTHFR play in Blutzucker?

MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in folate and homocysteine metabolism. Genetic variants, especially C677T (rs1801133), can lead to elevated homocysteine levels. Observational studies have linked higher homocysteine to increased risk of insulin resistance and type 2 diabetes, possibly through oxidative stress, endothelial dysfunction, or impaired methylation. However, the effect is modest and not directly causal. MTHFR does not directly regulate blood glucose; its influence is indirect via one-carbon metabolism. Evidence is human-moderate (association studies, no robust RCTs). A single MTHFR SNP alone is insufficient to guide personalized diet or supplementation for blood sugar control. Folate or B-vitamin supplements lower homocysteine but have not been proven to improve glycemic outcomes. For abnormal blood sugar, focus on established markers (HbA1c, fasting glucose) and lifestyle factors.