Questions about everyday life with weight-loss injections (e.g., semaglutide/Wegovy) are common. Strong evidence from large RCTs (STEP program) shows GLP-1 agonists can achieve 10–15 % weight loss on average – but only when combined with diet and exercise. The injection is not a magic bullet; side effects like nausea, vomiting, and diarrhea are frequent, especially during titration. Long-term sustainability after discontinuation is uncertain – many regain weight. Direct-to-consumer DNA tests (like MyBody‑X) cannot predict individual dosing or success; genetic effects on weight are small (e.g., FTO variant ~0.3 kg/m² per allele). Clinical guidelines mandate medical supervision due to contraindications (e.g., thyroid C-cell tumors, pancreatitis risk). Evidence: human-strong (RCTs). Safety note: prescription-only, under medical supervision.
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