Can tTG IgA help with longevity?

tTG IgA (tissue transglutaminase antibodies) is a well-established biomarker for celiac disease, not for longevity. A positive result indicates an autoimmune response to gluten, which if untreated can lead to intestinal damage, nutrient malabsorption, and chronic inflammation—factors that can impair health. In that indirect sense, diagnosing and treating celiac disease with a gluten-free diet may improve long-term health outcomes and potentially lifespan by preventing complications. However, there is no evidence that tTG IgA testing benefits longevity in individuals without celiac disease. The test is not validated as an anti-aging or longevity intervention. Caution: a positive test requires medical follow-up; a negative test does not rule out celiac disease entirely. Evidence: unclear, as no direct longevity studies exist.