What role does VKORC1 play in longevity?

VKORC1 encodes an enzyme that recycles vitamin K, thereby regulating blood clotting factors and matrix Gla proteins. Through these pathways, VKORC1 could theoretically influence vascular calcification and bone health in aging – both factors linked to lifespan. However, no robust human studies directly associate VKORC1 variants with longevity. Evidence is limited to pharmacogenetic data (warfarin dosing) and animal models. A DNA test for VKORC1 cannot predict your life expectancy. The clinical relevance for longevity remains speculative. Beware of exaggerated marketing claims: genetics is only a small piece in a complex puzzle of environment, diet, and lifestyle.