Is VKORC1 useful for fatigue?

VKORC1 encodes vitamin K epoxide reductase, a key enzyme in vitamin K metabolism and blood coagulation. Its established clinical utility is in pharmacogenetics: variants predict individual warfarin dose requirements. There is no credible scientific evidence linking VKORC1 polymorphisms to fatigue or energy levels. Fatigue is a complex, multifactorial symptom influenced by sleep, nutrition, stress, physical activity, mental health, and underlying medical conditions. A DNA test for VKORC1 provides no actionable insight for fatigue. Any claim that VKORC1 is useful for fatigue is unsupported by evidence and likely stems from marketing or misinterpretation. Individuals experiencing persistent fatigue should seek medical evaluation rather than rely on single-gene tests.