What to watch with Folsäure and allergy?

When it comes to folic acid and allergies, caution is warranted because the evidence is mixed. Some observational studies suggest that high folic acid intake during pregnancy may slightly increase the risk of asthma or atopy in children, while others find no association or even a protective effect. Mechanistically, folate may influence immune regulation via epigenetic modifications (DNA methylation). However, effects are small and depend on dose, timing, and genetic variants like MTHFR C677T. For adults with existing allergies, there is no clear evidence that folic acid worsens or improves symptoms. Important: High doses (>1 mg/day) can mask vitamin B12 deficiency, especially in vegans and older adults. MyBody-X tests analyze MTHFR variants, but clinical relevance for allergies is unclear. Recommendation: Standard supplementation (400–800 µg/day) is safe for most; allergy sufferers without deficiency should avoid high-dose preparations without medical advice. Evidence: mechanistic, mixed.