What to watch with FTO and longevity?

FTO variants (e.g., rs9939609) are strongly associated with higher BMI and increased appetite (GWAS, strong evidence). However, a direct effect on longevity is not established. Longevity is multifactorial: diet, exercise, inflammation, telomere length, and other genes. FTO may indirectly influence lifespan through obesity-related metabolic diseases. The effect size is moderate and modifiable by lifestyle. Most people with FTO risk variants live long if they maintain healthy habits. Do not self-label as having a 'bad gene'. Evidence: strong for BMI, weak for direct longevity. Caveat: No supplements or extreme diets based solely on FTO. Focus on balanced nutrition, physical activity, and regular health check-ups.