Can CYP1A2 help with Sport?

CYP1A2 encodes an enzyme that metabolizes caffeine, a common ergogenic aid in sports. The gene variant (rs762551) classifies individuals as fast (AA) or slow (AC/CC) metabolizers. Fast metabolizers may experience greater performance benefits from caffeine, such as improved endurance and focus, due to efficient clearance. Slow metabolizers are at higher risk for side effects like tachycardia, anxiety, and sleep disruption, with limited or no ergogenic advantage. Evidence from human studies supports this genotype–caffeine interaction, but effect sizes are moderate and context-dependent (dose, training status, habitual intake). A DNA test can reveal your CYP1A2 genotype, but it is not a standalone predictor of sports success. The MyBody-X test may include this SNP, but the provided context does not confirm it. Safety note: excessive caffeine can cause adverse cardiovascular effects. Use caffeine strategically and consult a professional.