What role does Folsäure play in Langlebigkeit?

Folic acid (vitamin B9) is crucial for DNA synthesis, repair, and methylation—processes directly linked to cellular aging and epigenetic changes. Deficiency can raise homocysteine, a risk factor for cardiovascular disease and cognitive decline. However, evidence for a direct longevity-extending effect of folic acid supplementation in humans is weak. Observational studies show associations between good folate status and lower mortality, but randomized controlled trials do not consistently confirm this. High doses may even pose risks (e.g., masking B12 deficiency). The provided context contains no specific information on folic acid and longevity. Therefore, this answer is based on general scientific knowledge. Evidence: mechanistic/observational, not conclusive.