Is IgG useful for stress?

The question of whether IgG (immunoglobulin G) is useful for stress requires careful scrutiny. IgG antibodies are often marketed in the context of food sensitivity testing, but the scientific evidence for their clinical utility in stress management is weak. While stress can influence immune function—for example, via cortisol-mediated shifts in antibody production—there is no validated role for routine IgG measurement in diagnosing or managing stress. Most commercial IgG food sensitivity tests lack robust evidence; major allergy organizations advise against their use. For stress, well-studied interventions include mindfulness, exercise, and sleep optimization. Genetic variants like COMT Val158Met (rs4680) or DRD2 Taq1A (rs1800497) may offer small insights into stress reactivity, but they are not deterministic. In summary, IgG is not a reliable or evidence-based tool for stress. Focus on lifestyle and professional support rather than unvalidated biomarker tests.