What role does tTG IgA play in fatigue?

tTG IgA (tissue transglutaminase IgA) is a well-established serological marker for celiac disease, an autoimmune condition triggered by gluten. Chronic fatigue is a common but non-specific symptom of celiac disease, potentially arising from malabsorption (iron, vitamin B12, folate deficiency), chronic inflammation, or associated autoimmune disorders. However, the provided knowledge context contains no direct evidence linking tTG IgA to fatigue. The documents cover DNA tests, hormone panels, and general fatigue, but not celiac serology. Therefore, the evidence from this source is unclear. A positive tTG IgA test always requires medical follow-up (duodenal biopsy) before recommending a gluten-free diet. Fatigue has many causes – a single marker cannot explain it. Consumers should understand that home tests for tTG IgA are screening tools only and do not replace a clinical diagnosis.