Evidence check: Skincare DNA in the context of Wechseljahre

This request evaluates the evidence for skincare DNA tests in the context of menopause. The provided context lacks any direct studies or data on this topic. Skincare DNA tests are often marketed with claims about collagen breakdown, antioxidant capacity, or hormone sensitivity. During menopause, declining estrogen indeed causes skin dryness, loss of elasticity, and wrinkling. However, the scientific basis for personalized skincare based solely on single gene variants (e.g., GPX1, FADS1, APOA5) is very weak. Most of these markers have small effect sizes and are not validated for clinical decisions. Lifestyle factors (diet, UV protection, moisturizing) and hormonal status have a much stronger impact on skin health than the tested SNPs. There is no proven benefit of such DNA tests for guiding skincare during menopause. Caution is warranted: supplements (e.g., selenium, omega-3s) should not be taken based solely on genetic test results, as excess can be harmful. Evidence: predominantly marketing, lacking robust clinical data.