How are CRP Entzündung and Stress related?

CRP (C-reactive protein) is a key inflammatory marker produced in the liver. Psychological stress activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, releasing cortisol and catecholamines. Chronically elevated cortisol can dysregulate immune function, leading to low-grade systemic inflammation reflected by increased CRP. Numerous human studies (e.g., prospective cohorts) show a significant association between chronic stress, depressive symptoms, and elevated hsCRP. However, CRP is non-specific – infections, obesity, smoking, and autoimmune diseases also raise it. The effect size of stress on CRP is moderate and varies individually. Genetic factors (e.g., CRP polymorphisms) and lifestyle (sleep, exercise, diet) modulate the relationship. In practice, stress reduction (mindfulness, physical activity) can lower CRP, but a single CRP value should not be interpreted in isolation. Evidence: strong human studies, but no monocausal link.