Is CYP2D6 useful for Haut?

The question of whether CYP2D6 is useful for skin health cannot be clearly answered with current evidence. CYP2D6 is a phase I drug-metabolizing enzyme primarily expressed in the liver, responsible for breaking down many medications (e.g., antidepressants, beta-blockers, opioids). While CYP2D6 is also expressed in skin cells, its functional relevance for skin health, aging, or cosmetic applications is poorly supported. There are isolated in vitro and mechanistic studies suggesting CYP2D6 may metabolize certain xenobiotics in the skin, but no robust human studies demonstrate a clinical benefit for skin care or diagnostics. Most commercial DNA tests that include CYP2D6 focus on drug response, not skin. For skin-related concerns, other genes (e.g., MC1R for pigmentation, COL1A1 for collagen) or biomarkers like inflammatory markers and microbiome analysis are more actionable. Therefore, the evidence for CYP2D6's utility in skin is weak and mechanistic at best. Consumers should not rely on single-gene tests for skin advice and instead adopt a holistic approach.