What to watch with VKORC1 and Langlebigkeit?

VKORC1 encodes vitamin K epoxide reductase, crucial for recycling vitamin K. Variants (e.g., -1639G>A) alter warfarin sensitivity and vitamin K requirements. For longevity, the link is indirect: vitamin K-dependent proteins (matrix Gla protein, osteocalcin) help prevent vascular calcification and maintain bone health. However, evidence is mostly mechanistic; no robust longevity studies directly connect VKORC1 variants to extended lifespan. Consumer DNA tests often overstate the clinical impact. Key takeaways: ensure adequate vitamin K intake (leafy greens, broccoli) and, if on anticoagulants, adjust dosing based on genotype under medical supervision. For healthy individuals not on medication, VKORC1's effect on longevity is modest and modifiable by diet. The real drivers of longevity remain overall lifestyle, diet, and other genetic factors.